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Web site:
http://cornel.uckac.edu
Research Statement
Most
research in the Cornel laboratory focuses on control and biology of Culex
mosquitoes. Development of resistance to pesticides in disease vectors is an
ongoing issue that requires a multidisciplinary approach to fully understand.
Several projects are underway and they are:
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Use of chemistry/biochemistry to track metabolism or detoxification of
pyrethroids in mosquitoes with the intention of developing more
sensitive and selective assays than what is current available for
detecting and monitoring enzyme mediated pyrethroid resistance.
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Developing polytene chromosome maps and examining chromosomal
rearrangements between members of the Cx. pipiens complex
members. Our intention is to use polytenes as population genetic tools
to, investigate gene flow between members of the Cx. pipiens
complex, and to physically locate genes of interest by in situ
hybridization. Other population genetic markers such as microsatellites
and mitochondrial DNA are being used to complement polytene chromosomes
so that eventually we will be able to make predictions about dispersal
and spread of insecticide resistance genes amongst the complex members
and develop insecticide resistance management strategies.
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GIS technology and assays and results developed and obtained from the
above two projects are being integrated to examine linkage between
agricultural pesticide usage and selection of insecticide resistance in
mosquitoes of California.
For
more detailed descriptions of the above three projects and others on
malaria vectors and the tick Boophilus microplus consult the
following website: http://cornel.uckac.edu.
Selected Publications
Cornel, A.J., R.D. McAbee, J. Rasgon, M.A. Stanich,
T.W. Scott, and M. Coetzee. 2003. Differences in extent of genetic
introgression between sympatric Culex pipiens and Culex
quinquefasiatus (Diptera:Culicidae) in California and South Africa .
J. Med. Entomol. 40(1): 36-51.
Cornel, A.J., M.A.
Stanich, R.D. McAbee, and S. Mulligan. 2002.
High level methoprene resistance in the
mosquito Ochlerotatus nigromaculis (Ludlow) in Central California.
Pest Mgmt. Sci. 58:791-798.
Zheng, L., A.J. Cornel, R.Wang, H.Erfle, H.Voss,
W.Ansorge, F.C. Kafatos, F.H. Collins. 1997.
Quantitative trait loci for refractoriness of
Anopheles gambiae to Plasmodium cynomologi B. Science
276:425-428.
Cornel, A.J., M.Q.
Benendict, C.S. Rafferty, A.J. Howells, and F.H. Collins. 1997. Transient
expression of the Drosophila melanogaster cinnabar gene rescues eye
color in the white eye (WE) strain of Aedes aegypti. Insect.
Biochem. Molec. Biol. 27(12):993-997. |
